MULTICOMPONENT THERAPY METHOD FOR LOWER LIMB TROPHIC ULCERS OF VENOUS ETIOLOGY Russian patent published in 2017 - IPC A61K31/522 A61K31/7048 A61P17/02 

FIELD: medicine.

SUBSTANCE: multicomponent therapy is applied including infusion and topical treatment. For I degree ulcers, trental 2% 1.3 mg/kg and 0.9% NaCl - 200 ml is introduced, Detralex is prescribed as 1 capsule 2 times a day, and 10 procedures of wound treatment with nitric oxide (NO) using the "PLASON" device at a distance of 15-20 cm from the wound surface are performed within 10 seconds per 1 cm² of area at NO temperature of 40°C, and NO concentration of 750 ppm with subsequent superimposition of a dressings with Kvotlan gel onto the trophic ulcer for a day. For II degree ulcers, Actovegin soultion is added to the complex for infusion at a dose of 4 mg/ml 0.9% NaCl - 250 ml and the time of ulcer treatment with nitric oxide is increased to 30 sec per 1 cm² of area. For III degree ulcers, Activegin solution dosage in the treatment complex for infusion is increased to 8 mg/ml, and the time of ulcer treatment with nitric oxide is increased to 60 sec per 1 cm² of area.

EFFECT: increased efficiency and reduced terms of treatment due to complex antioxidant, regenerative and vasoprotective action of the claimed therapeutic complex.

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