FIELD: chemistry.
SUBSTANCE: invention relates to a new crystal modification of (E)-dimethyl butenedioate, named β-modification, a method for its preparation and pharmaceutical composition on its basis, which can be used in the pharmaceutical industry and in medicine as a treatment for severe psoriasis, multiple sclerosis, necrobiosis lipoidica, granuloma annulare, lichen red hair, etc. new crystal dimethyl β-modification, characterised by a specific set of diffraction peaks (d, Е) and the intensity (Irel %) And two endothermic effects in the DSC curve at certain temperatures, a method for its preparation and its use for the preparation of a pharmaceutical composition.
EFFECT: new modification is a fluffy powder, white to off-white, odorless, soluble in chloroform, sparingly soluble in lower alcohols and slightly soluble in water.
3 cl, 6 dwg, 2 tbl, 4 ex
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