FIELD: pharmaceutics.
SUBSTANCE: invention relates to novel crystalline anhydrous modification N-{3-chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-[5-({[2-(methylsulfonyl)ethyl]amino}methyl)-2-furyl]-4-quinoline amine of bis (4-methylbenzenesulfonate) monohydrate (lapatinib ditosylate monohydrate), in particular γ-modification, characterized by certain set of diffraction maxima (d, Å) and their intensity (Irelative, %) and certain thermal effects and their temperatures on curve of differential scanning calorimetry, as well as to method of its production and use in pharmaceutical compositions as reversible selective inhibitor of intracellular tyrosine kinase receptor of epidermal growth factor for treating advanced and/or metastatic breast cancer.
EFFECT: increased biological activity.
4 cl, 5 dwg, 3 tbl, 4 ex
| Title |
Year |
Author |
Number |
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