LEVODOP PRODRUGS, BASED ON THEM COMPOSITIONS AND THEIR APPLICATION Russian patent published in 2009 - IPC C07C229/36 C07C235/60 C07D213/79 A61K31/216 A61K31/215 A61K31/24 A61K31/4409 A61K31/455 A61P25/16 

FIELD: chemistry.

SUBSTANCE: invention relates to levodop prodrugs, their stereoisomers, enantiomers or pharmaceutically acceptable salts and based on them pharmaceutical composition for ensuring slowed levodop release, as well as to versions of their application and methods of obtaining them, compounds can be applied for treatment or prevention of diseases in which levodop application is indicated. In general formula (I): , Q is selected from X-CO-; X is selected from -O- and -NH-; n equals integer number from 2 to 4; each R¹ and R² is independently selected from hydrogen, -OH, C_1-4alkyl and substituted C_1-4alkyl, where substituting group is -OH; R³ and R⁴ represent hydrogen; R⁵ is selected from hydrogen, C_1-4alkyl, phenyl, substituted phenyl, where each substituting group is independently selected from C_1-6alcoxy, C_1-6alkyl, halogen and -OH; C_3-8cycloalkyl, pyridyl, substituted pyridyl, where each substituting group is independently selected from C_1-6alkyl and C_1-6alcoxy; on condition that formula (I) compound is not a derivative of 1,3-dihexadecanoylpropane-1,2,3-triol.

EFFECT: elaboration of pharmaceutical composition for ensuring slowed levodop release.

48 cl, 4 dwg, 32 ex