POLYCYCLIC DERIVATIVES, METHOD FOR THEIR PRODUCTION AND THEIR PHARMACEUTICAL APPLICATION Russian patent published in 2017 - IPC C07D307/79 C07D407/12 C07D405/12 A61K31/343 A61P3/00 A61P3/10 

FIELD: pharmacology.

SUBSTANCE: invention relates topolycyclic derivatives represented by a compound of the general formula (I)

,

wherein A is -O-; L is -O-; ring B is phenyl; R¹, R² and R³ each is independently selected from the group consisting of halogen, hydroxyl, alkyl, wherein alkyl is optionally substituted by hydroxyl; R⁴ is selected from the group consisting of C_3-12cycloalkyl, heterocyclyl and heteroaryl, such as

, , , , ,

where cycloalkyl, heterocyclyl or heteroaryl are each optionally substituted by one or more groups selected from the group consisting of hydroxyl, cyano, nitro, alkyl, alkoxy, cycloalkyl, heterocyclyl, aryl, heteroaryl, -C(O)OR⁵, -OC(O)R⁵, -C(O)R⁵ and -S(O)_mR⁵; R⁵ is selected from the group consisting of hydrogen, alkyl, C_3-12cycloalkyl, wherein alkyl, cycloalkyl is each optionally substituted by hydroxyl; m is 2; n is 0; p is 0 or 1 and q is 2, 3 or 4 or its racemates, enantiomers, diastereomers and mixtures thereof, and pharmaceutically acceptable salts thereof, as well as methods for its preparation, containing its pharmaceutical compositions and its application as therapeutic agents, in particular as a GPR40 agonist, and to methods of treatment and prevention of diseases like diabetes, metabolic syndrome, etc.

EFFECT: increased efficiency of the composition and treatment method.

16 cl, 5 tbl, 36 ex