FIELD: pharmacology.
SUBSTANCE: oral dosage form comprises progestogen, estrogen, 5-methyl-(6S)-tetrahydrofolic acid or a pharmaceutically acceptable salt thereof, and at least one pharmaceutically acceptable excipient or carrier, and comprises granulating of progestogen and estrogen and at least one pharmaceutically acceptable excipient in the fluidized bed, mixing of 5-methyl-(6S)-tetrahydrofolic acid or the pharmaceutically acceptable salt thereof with granules, and further granulation by maintaining the fluidized bed and formation of a solid oral dosage form from granules.
EFFECT: compositions of the invention provide good stability of tetrahydrofolic acid during storage and at the same time provide a rapid release of estrogen and progestogen present in the composition.
14 cl, 3 dwg, 5 tbl, 6 ex
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