METHOD OF CORRECTION OF ENDOTHELIAL DYSFUNCTION AT PROGRESSIVE CURRENT OF OBJECTIVE ATHEROSCLEROSIS OF VESSEL LIMBS Russian patent published in 2017 - IPC A61K9/08 A61K31/5575 A61P9/10 

FIELD: medicine.

SUBSTANCE: against the background of basic therapy with drugs that improve microcirculation, antispasmodics, antiplatelet agents and statins, additionally intravenously injected ozonized saline solution once a day in a volume of 400 ml with an ozone concentration of 2-4 mg/l. Then, not earlier than 4-6 hours, Vasaprostan® is administered - 60 mcg of alprostadil dissolved in 250 ml of a 0.9% solution of sodium chloride or Ringer's solution, with an infusion rate of 80 ml/h, with a course of 10 days.

EFFECT: application of the invention allows stabilizing the progression of the atherosclerotic process, increasing the walking distance and reducing the risk of developing critical ischemia.

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