HIV INHIBITING 5-HETEROCYCLYL PYRIMIDINES Russian patent published in 2010 - IPC C07D401/04 C07D409/04 C07D405/04 C07D413/04 C07D413/14 C07D417/04 A61K31/506 A61P31/18 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to new compounds of formula (I) and to its pharmaceutically acceptable additive salts, optionally in the form of stereochemical isomer and exhibiting anti-HIV antiviral activity, particularly having HIV inhibitor properties and applied as a drug. In formula , -a¹=a²-a³=a⁴- represents a bivalent radical of formula -CH=CH-CH=CH-(a-1); -b¹=b²-b³-b⁴ - represents a bivalent radical of formula -CH=CH-CH=CH- (b-1); n is equal to 0, 1, 2, 3, 4; m is equal to 0, 1, 2; each R¹ independently represents hydrogen; each R² represents hydrogen; R^2a represents cyano; X₁ represents -NR¹-; R³ represents C_1-6alkyl, substituted cyano; C_2-6alkrnyl, substituted cyano; R⁴ represents halogen; C_1-6alkyl; R⁵ represents 5 or 6-member completely unsaturated cyclic system where one, two or three members of the cycle represent heteroatoms, each independently specified from the group consisting of nitrogen, oxygen and sulphur and where the rest members of the cycle represent carbon atoms; and where 6-member cyclic system can be optionally annelated with a benzene cycle; and where any carbon atom in the cycle can be independently optionally substituted with a substitute specified from C_1-6alkyl, amino, mono- and diC_1-4alkylamino, aminocarbonyl, mono-and diC_1-4alkylcarbonylamino, phenyl and Het; where Het represents pyridyl, thienyl, furanyl; Q represents hydrogen The invention also concerns a pharmaceutical composition.

EFFECT: preparation of the new anti-HIV antiviral compounds.

4 cl, 2 tbl, 22 ex