TIENOPYRIMYDINE [3,2-D] PRODUCTION, WHICH HAS INHIBITORY ACTIVITY AGAINST PROTEIN KINASES Russian patent published in 2017 - IPC C07D495/04 A61K31/519 A61P35/00 

FIELD: chemistry.

SUBSTANCE: invention relates to thieno [3,2-d] pyrimidine of formula

in which A represents C_6-10aryl or 5-10 membered heteroaryl; W represents O, NH or -NHNH-; X and Y are each independently CH or N; Z is hydrogen or NR³R⁴, wherein said R³ and R⁴ are each independently hydrogen, C_1-6alkyl or - (CH₂)_q-B, B represents NR⁵R⁶ or C_3-6cycloalkyl; R1 It represents hydrogen or C_1-3alkyl, wherein said alkyl is unsubstituted or substituted by one or more halogen atoms; each R² independently represents hydrogen, halogen, -CF₃-OH, -CN, C_1-6alkoxy, C_1-6alkyl, C_2-4alkynyl, -NR⁷R⁸, -NHSO₂R⁹, -SO₂R¹⁰, -C(O)R¹¹, -NHC(O)R¹², -S(O)R¹⁴, 5-10 membered heterocycloalkyl, C_6-10aryloxy or 5-10 membered heteroaryl, wherein said R² is attached to A with Using - (CH₂)_p- or substituted by C_1-4alkyl, C_2-4alkynyl or one or more halogen atoms; R⁵, R⁶, R⁷, R⁸, R⁹, R¹⁰, R¹¹, R¹² and R¹⁴ are each independently hydrogen, -NH₂, C_1-6alkyl, C_1-6alkoxy, C_3-6cycloalkyl, mentioned alkyl, alkoxy or cycloalkyl being unsubstituted or substituted by one or more halogen atoms; or a pharmaceutically acceptable salt thereof.

EFFECT: compounds have inhibitory activity against protein kinases.

57 cl, 5 tbl, 128 ex