THIENO[3,2-d]PYRIMIDINE DERIVATIVES, POSSESSING INHIBITING ACTION WITH RESPECT TO PROTEINKINASE Russian patent published in 2014 - IPC C07D495/04 A61K31/519 A61K31/5377 A61K31/551 A61K31/496 A61P35/00 

FIELD: chemistry, pharmaceutics.

SUBSTANCE: invention relates to thieno[3,2-d]pyrimidine derivative of formula (I) or to its pharmaceutically acceptable salt: (I), where Y stands for -CH=CR¹-, -C≡C- or -C(=O)NR¹-; L stands for -C(=O)NR²-, -NR²C(=O)- or -NR²C(=O)NR²-; R¹ and R², each independently stands for H; R stands for H, a halogen atom, methyl or methoxy; E stands for phenyl or C_3-10heteroaryl, which is non-substituted or substituted with 1-2 substituents, consisting of a group, which includes a halogen atom, -CF₃, C_1-6alkyl, hydroxy-C_1-6alkyl, C_3-8cycloalkyl, -(CH₂)_n-C_1-6alkylamino, -(CH₂)_n-diC_1-6alkylamino, -(CH₂)_nC_1-6alkoxy, -(CH₂)_n-OS(=O)₂-C_1-6-alkyl, -(CH₂)_n-phenyl, -(CH₂)_n-C_2-5heteroaryl and -(CH₂)_n-C_4-6heterocycloalkyl, where C_3-10heteroaryl represents pyridine, isoquinoline, indole or isoxazole, C_2-5heteroaryl of radical -(CH₂)_n-C_2-5heteroaryl represents imidazole or pyrrol, C_4-6heterocycloalkyl of radical -(CH₂)_n-C_4-6heterocycloalkyl represents piperazine, morpholine, diazepam, pyrrolidine or piperidine, and phenyl, heteroaryl and heterocycloalkyl each independently, is non-substituted or substituted with substituent selected from a group, which consists of C_1-6alkyl, hydroxy-C_1-6alkyl, a halogen atom and diC_1-6alkylamino, n is equal to 0 or 1; and Z stands for H, -C(=O)R³, C_1-6alkyl, hydroxyC_1-6alkyl, C_3-8cycloalkyl, piperidine, phenyl or pyridine, where piperidine, phenyl and pyridine, each independently, is non-substituted or substituted with C_1-6alkyl, C_1-6alkoxy or R³-piperazinyl and R³ represents C_1-6alkyl or phenyl. The invention also relates to an intermediate compound for obtaining the claimed final compound of formula (I).

EFFECT: novel compound, which can be applied in medicine for the prevention or treatment of diseases, characterised by an anomalous growth of cells as a result of an excessive expression of proteinkinase, is obtained.

8 cl, 2 tbl, 128 ex