FIELD: pharmacology.
SUBSTANCE: invention is an acid-hydrolyzed composition for targeted drug delivery consisting of microgel particles dispersed in a solution having a size in the range of 0.1 to 10 mcm and comprising: a) a polymer backbone which is a PEG diacrylate crosslinked with Lys-Phe-Gly-Lys with Span 80 and Tween 80, having the total hydrophilic-lipophilic balance of 5.6; b) acid protease, which is pepsin, inactivated at neutral pH and activated at moderately acidic pH; c) a drug that does not break down during acid protease catalysis.
EFFECT: improved compoistion properties.
4 cl, 4 ex, 1 dwg
| Title |
Year |
Author |
Number |
| COMPOSITION FOR ORAL DELIVERY OF BIOACTIVE AGENTS |
2014 |
- Kharel Moti
- Kambalapalli Svetkha
|
RU2688136C1 |
| AQUEOUS COMPOSITION COMPRISING CHEMICAL MICROGEL BOUND WITH AQUEOUS POLYMER |
2002 |
- Bavuze Brjuno
- Destarak Matias
|
RU2276161C2 |
| HYDROGEL CONTAINING HYALURONIC ACID DERIVATIVE MODIFIED WITH GALLOL GROUP AS SUBSTRATE, AND ITS USE |
2018 |
- Te, Sun Vu
- Li, Chzhun-Sun
- Te, Chzhun Kho
- Li, Chzhon-Sun
|
RU2778054C2 |
| HEALING AGENT |
2003 |
- Ignatov Gennadij Gennadievich
- Pisarenko Leonid Vasil'Evich
- Khrupkin Valerij Ivanovich
|
RU2271814C2 |
| PHARMACEUTICAL DEPOT, CONTAINING N-{ 5-[(CYCLOPROPYLAMINO)CARBONYL]-2-METHYLPHENYL} -3-FLUORO-4-([PYRIDIN-2-YLMETHOXY)BENZAMIDE |
2009 |
- Behjtmehn Nikola Frehnsis
- Makfaul Filip Aleksander
- Nehsh Ajan Alun
|
RU2538702C2 |
| PREORAL DELIVERY SYSTEM FOR PROTEIN SUBSTANCE (OPTIONS), PROTECTIVE COATING FOR DELIVERY SYSTEM (OPTIONS) |
2014 |
- Khazanova Elena Sergeevna
- Egorov Dmitrij Vyacheslavovich
- Nogaj Sergej Yurevich
|
RU2665367C2 |
| WATER-DISPERSIBLE ORAL, ENTERAL AND LOCAL COMPOSITIONS FOR POORLY WATER-SOLUBLE DRUG PREPARATIONS CONTAINING POLYMER NANOPARTICLES IMPROVING PROPERTIES THEREOF |
2007 |
- Majtra Anirban
- Fel'Dman Georg
- Bisht Savita
|
RU2492872C2 |
| BIODEGRADABLE, SEMI-CRYSTALLINE, PHASE SEPARATED, THERMOPLASTIC MULTI-BLOCK COPOLYMERS FOR CONTROLLED RELEASE OF BIOLOGICALLY ACTIVE COMPOUNDS |
2012 |
- Stendam Rob
- Flipsen Teodorus Adrianus Kornelius
- Khimstra Kristin
- Zejdema Jokhan
|
RU2662818C2 |
| BIOADHESIVE SYSTEM FOR DELIVERING MEDICINAL PREPARATIONS |
2003 |
- Kirshner Mitchell I.
- Levinson R. Sol
- Rajli Tomas S.
- Khermelin Mark S.
|
RU2320322C2 |
| IMIDISED BIOPOLYMER ADHESIVE AND HYDROGEL |
2007 |
- Elisseeff Dzhennifer Kh.
- Strekhin Iossif A.
|
RU2486907C2 |
