FIELD: pharmacology.
SUBSTANCE: invention relates to 2-(((Z)-amino((Z)-2,4-dioxo-5-(2-oxo-2-phenylethylidene)pyrrolidin-3-ylidene)methyl)amino)-4,5,6,7-tetrahydrobenzo[b]thiophenecarboxylic acid of formula 1
,
which has analgesic activity.
EFFECT: compound with a high yield is obtained, which has a pronounced analgesic activity, as well as low toxicity.
1 tbl, 1 ex
| Title |
Year |
Author |
Number |
| 5-AMINO-1-(2-OXO-2-PHENYLETHYLIDENE)-3-(PYRROLIDINE-1-CARBONYL)-6,7,8,9-TETRAHYDROBENZO[4,5]THIENO[3,2-e]PYRROLO[1,2-a]PYRIMIDIN-2(1H)-ONE, WHICH HAS ANALGESIC ACTIVITY |
2023 |
- Parkhoma Kseniia Iurevna
- Lipin Dmitrii Vladimirovich
- Makhmudov Ramiz Ragibovich
- Shipilovskikh Sergei Aleksandrovich
|
RU2810252C1 |
| ETHYL ETHER 2-AMINO-(3-CYANO-4,5,6,7-TETRAHYDROBENZO[B]THIOPHEN-2-YL)-5-(2-(4-ETHYLPHENYL)-2-OXOETHYLIDENE)-4-OXO- 4,5-DIHYDRO-1H-PYRROL-3-CARBOXYLIC ACID WITH ANALGESIC ACTIVITY |
2023 |
- Shipilovskikh Sergei Aleksandrovich
- Makhmudov Ramiz Ragibovich
- Lipin Dmitrii Vladimirovich
- Parkhoma Kseniia Iurevna
|
RU2810070C1 |
| APPLICATION OF 2-[(1,4-DIOXO-1-R-4-(4-METHOXYPHENYL)BUT-2-ENE-2-YL)AMINO]-4,5,6,7-TETRAHYDROBENZO[b]THIOPHENE-3-CARBOXYLIC ACID AMIDES AS AN ANALGESIC MEDICINAL PRODUCT |
2021 |
- Shipilovskikh Sergej Aleksandrovich
- Rubtsov Aleksandr Evgenevich
- Makhmudov Ramiz Ragibovich
- Shipilovskikh Darya Aleksandrovna
|
RU2779193C1 |
| ETHYL ESTERS OF 2-[(1,4-DIOXO-4-PHENYL-1-(R-AMINO)BUT-2-EN-2-IL)AMINO]4,5,6,7-TETRAHYDROBENZO[b]THIOPHENE-3-CARBOXYLIC ACID WITH ANALGESIC ACTIVITY |
2021 |
- Shipilovskikh Sergej Aleksandrovich
- Rubtsov Aleksandr Evgenevich
- Makhmudov Ramiz Ragibovich
- Shipilovskikh Darya Aleksandrovna
|
RU2776068C1 |
| 4-OXO-N-(FURAN-2-YLMETHYL)-4-(4-CHLOROPHENYL)-2-((3-CYANO-4,5,6,7-TETRAHYDROBENZO[B]THIOPHEN-2-YL)AMINO)BUT-2-ENAMIDE WITH ANALGESIC ACTIVITY |
2022 |
- Shipilovskikh Sergei Aleksandrovich
- Makhmudov Ramiz Ragibovich
- Gorbunova Irina Aleksandrovna
- Okoneshnikova Elizaveta Aleksandrovna
|
RU2798425C1 |
| 4-(4-METHOXYPHENYL)-4-OXO-N-PHENYL-2-((3-CYANO-4,5,6,7-TETRAHYDROBENZO[b]THIOPHEN-2-YL)AMINO)BUT-2-ENAMIDE WITH ANALGESIC ACTIVITY |
2023 |
- Shipilovskikh Sergei Aleksandrovich
- Makhmudov Ramiz Ragibovich
- Gorbunova Irina Aleksandrovna
|
RU2810072C1 |
| N-R-AMIDES OF (Z)-2[(3-ETHOXYCARBONYL)-4,5,6,7-TETRAHYDROBENZO [b]THIEN-2-YL)AMINO]-4-PHENYL-4-OXOBUT-2-ENOIC ACIDS, HAVING ANALGESIC ACTIVITY |
2012 |
- Shipilovskikh Sergej Aleksandrovich
- Makhmudov Ramiz Ragibovich
- Rubtsov Aleksandr Evgen'Evich
|
RU2501795C1 |
| APPLICATION OF AN ANALGESIC AGENT BASED ON POTASSIUM 1,6-DIOXO-6-(4-CHLOROPHENYL)-2-CYANO-1-ETHOXY-4-[((3-ETHOXYCARBONYL)-4,5,6,7-TETRAHYDROBENZO[b]THIOPHENE-2-YL)AMINO]HEXA-2,4-DIENE-3-OLATE |
2021 |
- Shipilovskikh Sergej Aleksandrovich
- Rubtsov Aleksandr Evgenevich
- Makhmudov Ramiz Ragibovich
- Shipilovskikh Darya Aleksandrovna
|
RU2776070C1 |
| POTASSIUM 2-(4-BROMOPHENYL)-6-OXO-4-(PHENYLIMINO)-1,6-CYANO-1-((4-CYANO-3-TETRAHYDROBENZO[b]THIOPHEN-4,5,6,7-YL)AMINO)-2-ETOXYHEXA-2,4-DIENE-3-OLATE WITH ANALGESIC ACTIVITY |
2023 |
- Shipilovskikh Sergei Aleksandrovich
- Makhmudov Ramiz Ragibovich
- Lipin Dmitrii Vladimirovich
|
RU2810078C1 |
| (Z)-2-[(3-CARBAMOYL-4,5,6,7-TETRAHYDROBENZO[b]THIEN-2-YL)AMINO]-4-(4-R-PHENYL)-4-OXOBUT-2-ENOIC ACIDS, HAVING ANALGESIC ACTIVITY |
2012 |
- Shipilovskikh Sergej Aleksandrovich
- Rubtsov Aleksandr Evgen'Evich
- Makhmudov Ramiz Ragibovich
|
RU2503671C1 |
