FIELD: organic chemistry.
SUBSTANCE: invention relates to the field of organic chemistry, to new biologically active substances of the class 2-amino-4-aryl-4-dioxobutane acids. The proposed ethyl esters are 2-[(1,4-dioxo-4-phenyl-1-(R1-amino)but-2-en-2-yl)amino]-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid 1 a, b of the general formula have analgesic activity. Ethyl esters of 2-[(1,4-dioxo-4-phenyl-1-(R'-amino)but-2-en-2-yl)amino]-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid 1 a,b are obtained by the interaction of ethyl ether 2-[(2-oxo-5-phenyl-3(2H)-furanilidene)amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylic acid with 2-amino-4-methylpyrimidine or 2-aminothiazole. The resulting mixture is kept at 100°C for 4 hours, followed by the isolation of the target products by known methods.
EFFECT: compounds with high yields, having pronounced analgesic activity, as well as low toxicity were obtained.
1 cl, 1 tbl
| Title |
Year |
Author |
Number |
| APPLICATION OF AN ANALGESIC AGENT BASED ON POTASSIUM 1,6-DIOXO-6-(4-CHLOROPHENYL)-2-CYANO-1-ETHOXY-4-[((3-ETHOXYCARBONYL)-4,5,6,7-TETRAHYDROBENZO[b]THIOPHENE-2-YL)AMINO]HEXA-2,4-DIENE-3-OLATE |
2021 |
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|
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- Shipilovskikh Sergej Aleksandrovich
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|
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|
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|
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|
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|
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|
RU2503671C1 |
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|
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|
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