FIELD: organic chemistry; pharmaceuticals.
SUBSTANCE: invention relates to a new biologically active substance of 5-amino-3-pyrrolinones class. The following is disclosed: ethyl ester of 2-amino-(3-cyano-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)-5-(2-(4-ethylphenyl)-2-oxoethylidene)-4-oxo-4,5-dihydro-1H-pyrrole-3-carboxylic acid 1 with analgesic activity.
EFFECT: invention provides effective analgesic activity with low toxicity.
1 cl, 1 tbl, 3 ex
| Title |
Year |
Author |
Number |
| 2-((3-CYANO-4,5,6,7-TETRAHYDROBENZO[B]THIOPHEN-2-YL)AMINO)-4-(4-METHOXYPHENYL)-4-OXOBUTT-2-ENOIC ACID BENZYL ETHER WITH ANALGIC ACTIVITY |
2022 |
- Shipilovskikh Sergei Aleksandrovich
- Makhmudov Ramiz Ragibovich
- Gorbunova Irina Aleksandrovna
- Sharaveva Iuliia Olegovna
|
RU2798424C1 |
| POTASSIUM 2-(4-BROMOPHENYL)-6-OXO-4-(PHENYLIMINO)-1,6-CYANO-1-((4-CYANO-3-TETRAHYDROBENZO[b]THIOPHEN-4,5,6,7-YL)AMINO)-2-ETOXYHEXA-2,4-DIENE-3-OLATE WITH ANALGESIC ACTIVITY |
2023 |
- Shipilovskikh Sergei Aleksandrovich
- Makhmudov Ramiz Ragibovich
- Lipin Dmitrii Vladimirovich
|
RU2810078C1 |
| OBTAINING 6-(4-BROMOPHENYL)-6-OXO-1-(PHENYLIMINO)-2-CYANO-4-((3-CYANO-4,5,6,7-TETRAHYDROBENZO[b]THIOPHEN-2-YL)AMINO)-1-ETOXYHEXA-2,4-DIENE-3-OLATE POTASSIUM WITH ANALGESIC ACTIVITY |
2023 |
- Shipilovskikh Sergei Aleksandrovich
- Makhmudov Ramiz Ragibovich
- Lipin Dmitrii Vladimirovich
- Silaichev Pavel Sergeevich
|
RU2808997C1 |
| 2-CYANO-4-[1,6-DIOXO-6-(4-METHYLPHENYL)-1-ETOXY-4-(3-CYANO-4,5,6,7-TETRAHYDROBENZO[b]THIOPHEN-2-IL)AMINO]HEXA-2,4-DIEN-3-OLATE POTASSIUM WITH ANALGESIC ACTIVITY |
2022 |
- Shipilovskikh Sergei Aleksandrovich
- Makhmudov Ramiz Ragibovich
- Lipin Dmitrii Vladimirovich
- Kozlov Danil Anatolevich
|
RU2798429C1 |
| OBTAINING 2-((6-(2-METHOXYPHENYL)-3-OXO-2-ETHYL-2,3-DIHYDROPYRIDAZIN-4-YL)AMINO)-4,5,6,7-TETRAHYDROBENZO[b]THIOPHENE-3-CARBONITRILE WITH ANALGESIC ACTIVITY |
2023 |
- Shipilovskikh Sergei Aleksandrovich
- Makhmudov Ramiz Ragibovich
- Lipin Dmitrii Vladimirovich
|
RU2808995C1 |
| ETHYL ETHER OF 2-(((Z)-AMINO((Z)-2,4-DIOXO-5-(2-OXO-2-PHENYLETHYLIDENE)PIRROLIDINE-3-YLIDEN)METHYL)AMINO)-4,5,6,7-TETRAHYDROBENZO[b]THIOPHENCARBOXYLIC ACID WITH ANALGETIC ACTIVITY |
2016 |
- Shipilovskikh Sergej Aleksandrovich
- Rubtsov Aleksandr Evgenevich
- Makhmudov Ramiz Ragibovich
- Vasileva Anastasiya Yurevna
|
RU2631649C1 |
| APPLICATION OF AN ANALGESIC AGENT BASED ON ETHYL ETHERS OF 2-[(5-HYDROXY-5-PHENYL-2-OXO-1-R-2,5-DIHYDRO-1H-PYRROLE-3-YL)AMINO]-4,5,6,7-TETRAHYDROBENZO[b]THIOPHENE-3-CARBOXYLIC ACID |
2021 |
- Shipilovskikh Sergej Aleksandrovich
- Rubtsov Aleksandr Evgenevich
- Makhmudov Ramiz Ragibovich
- Shipilovskikh Darya Aleksandrovna
|
RU2776072C1 |
| N-(3-CYANO-4,5,6,7-TETRAHYDROBENZO[b]THIEN-2-YL)AMIDE 1-(4-BROMOBENZOYL)-5-HYDROXY-3-(4-METHYLPHENYL)-4,5-DIHYDRO-1H-PYRAZOLE-5-CARBOXYLIC ACID, HAVING ANALGESIC ACTIVITY |
2014 |
- Shipilovskikh Sergej Aleksandrovich
- Rubtsov Aleksandr Evgen'Evich
- Makhmudov Ramiz Ragibovich
- Panchenko Aleksej Olegovich
|
RU2564413C1 |
| AMIDE (E)-2-AMINO-4-OXO-5-(2-OXO-2-PHENYLETHYLIDENE)-1-(3-ETHOXYCARBONYL)-4,5,6-7-TETRAHYDROBENZO[B]THIOPHEN-2-YL)4,5-DIHYDRO-1H-PYRROLE-3-CARBOXYLIC ACID, HAVING ANTIMICROBIAL ACTIVITY |
2020 |
- Shipilovskikh Sergej Aleksandrovich
- Rubtsov Aleksandr Evgenevich
- Makhmudov Ramiz Ragibovich
- Tkachenko Aleksandr Georgievich
- Nesterova Larisa Yurevna
|
RU2738405C1 |
| 4-(4-METHOXYPHENYL)-4-OXO-N-PHENYL-2-((3-CYANO-4,5,6,7-TETRAHYDROBENZO[b]THIOPHEN-2-YL)AMINO)BUT-2-ENAMIDE WITH ANALGESIC ACTIVITY |
2023 |
- Shipilovskikh Sergei Aleksandrovich
- Makhmudov Ramiz Ragibovich
- Gorbunova Irina Aleksandrovna
|
RU2810072C1 |
