FIELD: pharmacology.
SUBSTANCE: dosage form in the form of a pill according to this invention has a percentage of methanesulfonate hydrate of 1-cyclopropyl-8-(difluoromethoxy)-7-[(1R)-1-methyl-2,3-dihydro-1H-isoindole-5-yl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid from 80 wt % to 97.5 wt %.%. The pill has a size smaller than 200 mg of the commercially available Geninax pill.
EFFECT: compliance with the drug regimen is improved, washability is high, crushing strength and abrasion resistance are high, the invention withstands film coating and transportation and is suitable as a methanesulfonic acid hydrate pill of chemical compound A.
13 cl, 29 ex, 6 tbl
