METHOD FOR PRODUCTION OF BIOLOGICALLY ACTIVE SUBSTANCE BETA-CHLORINE -L-ALANINE Russian patent published in 2017 - IPC A23L29/00 A23L33/00 A23L33/175 C07C227/00 

FIELD: chemistry.

SUBSTANCE: method for production of biologically active substance β-chlorine-L-alanine consists in the fact that 5 g of L-serine is added to 25 ml of dioxane dried above molecular sieve 3A or 4A in a three-neck flask. Then the product is saturated with hydrogen chloride dried by passing through sulfuric acid two times. 2.5 g of thyonyl chloride is added to the solution and the solution is mixed for 3-4 h at a temperature of 60-65°C. The solution is cooled to 5-10°C and β-chlorine-L-alanine hydrochloride residue is dried. The residue is dissolved in water, 2-3 ml of hydrochloric acid and 0.2-0.3 g of activated carbon are added, and the solution is filtered. Saturated lithium hydroxide solution is used to adjust pH value of the solution to 5.5, 45-50 ml of acetone is added and the solution is cooled to 0-5°C for 1-2 h. Precipitated crystals are washed with acetone and dried.

EFFECT: increased output of beta-chlorine-L-alanine of suitable quality.

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