FIELD: medicine.
SUBSTANCE: for the transdermal delivery of biologically active substances (BAS), the application of containers with immobilized BAS to the surface of the skin is carried out, followed by transportation through the appendages of the skin. Porous calcium carbonate particles in a crystallographic modification of a vaterite with a size of less than 1,5 mcm are used as the containers. Transportation is carried out by exposing to ultrasound with an intensity of 0.1-1 W/cm2 with a duration of 1-4 minutes.
EFFECT: effective filling of the hair follicles with particles while accelerating the procedure of introduction and providing the possibility to control the release duration of biologically active substances.
4 cl, 2 tbl, 47 dwg, 15 ex
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Authors
Dates
2017-10-19—Published
2016-08-24—Filed