FIELD: chemistry.
SUBSTANCE: invention relates to the synthesis of substituted 1,2,3,4-tetrahydropyrido[3',2':4,5]thiene[3,2-d]pyrimidine-4-ones of general formula 1, including the reaction between 3-amino -6-methylthieno[2,3-b]pyridine-2-carboxamides 2a, b and aromatic aldehydes 3a, b or 3-(4-methoxyphenyl')-pyrazole-4-carbaldehyde 3b, the tetrahydropyrimidinone ring according to the invention is formed by boiling the reagents in acetic acid, which is used simultaneously as an acid catalyst and solvent for 4.5-6 hours in the molar ratio of reactants of 2: 3 and the acetic acid ratio of 1:1.1:77.3, respectively:
1a:R1=Me, R2=o-C6H4NO2; 1b:R1=CH2OMe,
1c:R1=CH2OMe, R2=C6H2(OMe)3(2,3,4).
EFFECT: increasing the selectivity, decreasing the reaction time and increasing the yields of target products.
1 tbl, 7 ex
| Title | Year | Author | Number |
|---|---|---|---|
| 7',9'-DIMETHYL-3'-ARYL-1'-SPIRO[INDENE-2,2'-PYRIDO[3',2':4,5]THIENO]3,2-D]PYRIMIDINE]-1,3,4'(3'H)TRIONS, METHOD FOR SYNTHESIS AND APPLICATION THEREOF AS ANTIDOTES TO 2,4-D ON SUNFLOWER | 2020 |
|
RU2754220C1 |
| N-ACYLATED 3-AMINO-4,6-DIMETHYLTHIENO[2,3-b]PYRIDINE-2-CARBOXAMIDES AS ANTIDOTES OF 2,4-D ON SUNFLOWER | 2011 |
|
RU2475490C1 |
| METHOD OF OBTAINING FURYLHETARYLMETHANES WITH THIENO[2,3-B]PYRIDINE FRAGMENT | 2007 |
|
RU2346947C1 |
| METHOD OF PRODUCING SUBSTITUTED PYRIDO[3',2':4,5]THIENO[3,2-d]PYRIMIDINE-2,4(1H,3H)-DIONES | 2023 |
|
RU2814735C1 |
| 1,2,3,4-TETRAHYDROPIRIDO[3',2':4,5]THIENO-[3,2-D]-PYRIMIDIN-4-ONES AS ANTIDOTES OF HERBICIDE WITH HORMONAL EFFECT OF 2,4-DICHLOROPHENOXYACETIC ACID | 2003 |
|
RU2241002C1 |
| 2,4-DICHLOROPHENOXYACETIC ACID HERBICIDE ANTIDOTE FOR SUNFLOWER | 2014 |
|
RU2557550C1 |
| CERTAIN PROTEIN KINASE INHIBITORS | 2015 |
|
RU2671494C2 |
| SUBSTITUTED 4-(SELENOPHEN-2(OR 3)-YLAMINO) PYRIMIDINE COMPOUNDS AND METHODS OF USE THEREOF | 2011 |
|
RU2597609C2 |
| HETEROCYCLIC DERIVATIVES AND USE THEREOF | 2015 |
|
RU2711502C2 |
| BICYCLIC PYRIDINES AND ANALOGUES AS SIRTUIN MODULATORS | 2010 |
|
RU2550821C2 |
