FIELD: chemistry.
SUBSTANCE: invention relates to the synthesis of substituted 1,2,3,4-tetrahydropyrido[3',2':4,5]thiene[3,2-d]pyrimidine-4-ones of general formula 1, including the reaction between 3-amino -6-methylthieno[2,3-b]pyridine-2-carboxamides 2a, b and aromatic aldehydes 3a, b or 3-(4-methoxyphenyl')-pyrazole-4-carbaldehyde 3b, the tetrahydropyrimidinone ring according to the invention is formed by boiling the reagents in acetic acid, which is used simultaneously as an acid catalyst and solvent for 4.5-6 hours in the molar ratio of reactants of 2: 3 and the acetic acid ratio of 1:1.1:77.3, respectively:
1a:R1=Me, R2=o-C6H4NO2; 1b:R1=CH2OMe,
1c:R1=CH2OMe, R2=C6H2(OMe)3(2,3,4).
EFFECT: increasing the selectivity, decreasing the reaction time and increasing the yields of target products.
1 tbl, 7 ex
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Authors
Dates
2017-10-26—Published
2016-11-23—Filed