FIELD: chemistry; pharmacology.
SUBSTANCE: invention relates to fine organic synthesis and pharmacology, specifically to a method of producing pyrido[3',2':4,5]thieno[3,2-d]pyrimidine-2,4(1H,3H)-diones, of interest as intermediate antimicrobial compounds and agents with potential anticancer action. Method of producing pyrido[3',2':4,5]thieno[3,2-d]pyrimidine-2,4(1H,3H)-diones of general formula 1 based on use of 3-aminothieno[2,3-b]pyridine-2-carboxamides as starting compounds and is characterized by that 3-aminothieno[2,3-b]pyridine-2-carboxamides are reacted with 1,1'-carbonyldiimidazole in boiling dioxane for 3 hours.
formula 1,
where R=R2=CH3, R1=H, R=R1=R2=CH3 or R+R1=(CH2)3, R2=2-furyl.
EFFECT: providing a method of producing end products using non-toxic reagents while maintaining synthesis efficiency.
1 cl, 3 ex
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