SUBSTITUTED 4-(SELENOPHEN-2(OR 3)-YLAMINO) PYRIMIDINE COMPOUNDS AND METHODS OF USE THEREOF Russian patent published in 2016 - IPC C07D421/12 C07D471/04 C07D487/04 C07D495/04 C07D491/48 C07D513/04 C07D517/04 A61K31/5377 A61K31/517 A61K31/519 A61P35/00 

FIELD: chemistry.

SUBSTANCE: present invention relates to selenophen compound of formula or its pharmaceutically acceptable salt, solvate or hydrate. Ring A is a conjugated benzene ring; 6-member aromatic conjugated ring containing one nitrogen atom; 5-member aromatic conjugated ring containing one or two heteroatoms selected from oxygen, nitrogen,sulfur and selenium, provided that there is no more than one oxygen atom or sulphur or selenium; such rings include pyridine, pyridazine, pyrazine, pyrimidine, thiophene, furan, pyrrole, selenophen, imidazole, pyrazole, oxazole, isoxazole, thiazole and isothiazole; where ring A is substituted with one, two or more groups independently selected from hydrogen, amino, thiol, C_1-6alkyl and C_1-6alkoxy. Y represents N. X represents O or NR⁶, where R⁶ is selected from hydrogen, C_1-6alkyl and galogenoC_1-6 alkyl. X can be connected in 2-m, or in 3-m position selenophen ring. R¹, R², R³ and R⁴ independently selected from hydrogen, nitro, C_1-6alkyl, C_1-4alkoxycarbonyl, aminokarbonyl and aminoC_1-6 alkyl. Also disclosed is a group of specific compounds, methods of producing selenophen compounds and pharmaceutical composition.

EFFECT: present invention enables to obtain selenophen compounds used for treating, inhibiting or controlling a cell proliferative disorder in a warm-blooded animal.

29 cl, 1 dwg, 2 tbl, 31 ex