PREPARATIONS OF THERMO-ABRASIVE HYDROGEL FOR APPLICATION IN TREATMENT OF UTERTAL DISORDERS Russian patent published in 2017 - IPC A61K9/10 A61K38/48 A61K47/10 A61K47/38 A61P13/10 

FIELD: pharmacology.

SUBSTANCE: invention is a composition of a biocompatible, mucoadhesive, thermoreversible hydrogel comprising a botulinum toxin and comprising at least one thermoreversible gelling agent selected from the group consisting of poloxamers, methylcellulose, hydroxypropylmethylcellulose, alginates, pH-controlled gellants, or any combination thereof, And at least one component selected from the group consisting of mucoadhesiveness enhancers and thickeners selected from the group consisting of polycarbophil, poly crosslinked acrylic acid, polymethacrylates, divinyl glycol, polyethylene glycol, polyethylene oxide, copolymer of vinylpyrrolidone and vinyl acetate, cellulose, microcrystalline cellulose, cellulose derivatives, gelatin, starch, starch derivatives, Gum, Dicalcium phosphate, lactose, sucrose, polyvinylpyrrolidone, polyvinyl alcohols, partially hydrolyzed polyvinyl acetate, polysaccharides, waxes, fats, fatty acid derivatives, hyaluronic acid, chitosan, carrageenan, carbomers, eudragit and any combination thereof for use in the treatment of bladder disorders, the treatment comprising applying the composition to the bladder cavity and does not include any step of injecting botulinum toxin into the wall of said bladder.

EFFECT: maintaining the stability of botulinum toxin during the instillation process, and after releasing it from the gel, enhancing the effect of botulinum toxin.

18 cl, 2 ex, 1 tbl, 3 dwg