FIELD: pharmacology.
SUBSTANCE: group of inventions is a pharmaceutical or cosmetic composition for use against hair loss wherein a compound selected from compounds of the formula: (II) H2N-(CH2)3-N1(CH3)-(CH2)4-NH2, (III) H2N-(CH2)3-N1(C6H11)-(CH2)4-NH2, (IV) H2N-(CH2)3-N1(C2H5)-(CH2)4-NH2, (V) H2N-(CH2)3-N1(C3H7)-(CH2)4-NH2, (VI) H2N-(CH2)3-N1(C4H9)-(CH2)4-NH2, or a pharmaceutically acceptable salt thereof, is mixed with excipients suitable for topical application to the scalp, as well as a N1-isobutylspermidine compound or a N-(3-aminopropyl)-N1-isobutyl-1,4-butanediamine of the formula: (VI) H2N-(CH2)3-N1(C4H9)-(CH2)4-NH2. These compounds are stable with respect to air and can effectively use the invention for topical application to the scalp without conversion to oxidized by-products.
EFFECT: inventions provide a more active action against alopecia in comparison with spermidine.
19 cl, 9 dwg, 11 ex
