INTERMEDIATE COMPOUNDS AND METHODS OF CALICHEAMICIN DERIVATIVE SYNTHESIS Russian patent published in 2017 - IPC C07C319/20 C07C319/28 

Abstract RU 2640197 C1

FIELD: chemistry.

SUBSTANCE: invention relates to intermediate compounds of the formula I , where R12 is selected from C1-C8-alkyl with a straight and branched chain; each R10 is independently selected from hydrogen, R12 and -OR12; each R8 and R9 are independently selected from C1-C8-alkyl with a straight and branched chain; r is 0; G is oxygen; Z1 is C1-C5-alkyl with a straight or branched chain; Ar is a 1.2-, 1.3 - or 1.4-phenylene; W is selected from -O - and -S-; and Y is a (C1-C6)alkylene group with a straight or branched chain, and also to the methods of synthesis and purification of calicheamicin derivatives.

EFFECT: improving the properties of compounds.

24 cl, 8 ex

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RU 2 640 197 C1

Authors

Dugger Robert Wayne

Letendre Leo Joseph

Patel Vimalkumar Babubhai

Prashad Amarnauth Shastrie

Zhang Chunchun

Dates

2017-12-27Published

2014-10-28Filed