TRIHETEROCYLIC COMPOUNDS, PHARMACEUTICAL COMPOSITIONS THEREOF AND METHODS FOR CANCER TREATMENT Russian patent published in 2009 - IPC C07D403/14 C07D403/04 C07D405/14 C07D413/14 A61K31/404 

FIELD: chemistry, medicine.

SUBSTANCE: invention refers to the triheterocylic compounds of formula (Ia) and their pharmaceutically acceptable salts used as growth inhibitors of the cancer or tumor cells, to the preparation method and pharmaceutical compositions thereof, to the treatment method used aforesaid compounds as well as to the intermediates of formula (II) the to the method of its preparation. In general formulas (Ia) and

, Q₁ is -N(R₁)-; Q₂ is -C(R₃)-; Q₃ is -C(R₅)-; Q₄ is -C(R₉)-; R₁ is -Y_m(R_a), where -R_a is -H, -OH, -C(O)R₁₄, -O-C(O)R₁₄, -C(O)N(R₁₄)₂, -C(O)OR₁₄, -OS(O)₂ONa-; R₂ is -H; R₃, R₄ and R₅ independently are -Y_m(R_b), where R_b is -H, halogen, -C₁-C₈ alkyl, -O-(C₁-C₈ alkyl) or -OR₁₄, -at condition that if value m of radical Y_m(R_b) is equal 0, then R₅ is not H; R₆ is -H; R₇ is -Y_m-(R_C), where -R_C is -O-(C₁-C₈ alkyl) or -NH(phenyl), R₈ is -Y_m(R_d), where - R_d is -H, -OH, R₉, R₁₀, R₁₁, R₁₂ and R₁₃ independently are -Y_m(R_e), where R_e is -H, halogen, 5-6-membered heterocycle containing 2 heteroatoms selected from N or O, -OR₁₄, or -O-C(O)OR₁₄; every R₁₄ independently is -H, -C₁-C₈ alkyl, -phenyl, 5-6-membered heterocycle containing one heteroatom being S; every Y independently is -C₁-C₈ alkylene-; every m independently is equal 0 or 1.

EFFECT: claimed compounds can find application for treatment of different cancer species.

41 cl, 4 tbl, 4 dwg, 8 ex