FIELD: medicine.
SUBSTANCE: method for production of a bioactive tissue growing composite comprising hyaluronic acid or a salt thereof as a matrix and polylactide microparticles or glycolide copolymers thereof as a filler comprising reacting of solid-phase powders of hyaluronic acid or a salt thereof and a polylactide or copolymers thereof with glycolide under conditions of simultaneous exposure to pressure ranging from 20 to 50 MPa and shear deformation in a mechanochemical reactor at a temperature of 20 to -20 °C.
EFFECT: method allows to obtain a bioactive composite for tissue growing in one-step mode with high yield and the necessary filler content for formation of a highly plastic biodegradable implant based on this composite.
14 cl, 8 dwg, 11 ex
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| SOLID-PHASE METHOD OF PRODUCING WATER-SOLUBLE BIOACTIVE NANOCOMPOSITE BASED ON MELANIN-MODIFIED HYALURONIC ACID SALT AND GOLD NANOPARTICLES | 2013 |
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| COMPOSITE MATERIAL FOR CORRECTION OF AESTHETIC AND AGE-RELATED SKIN CHANGES AND METHOD FOR PRODUCTION THEREOF | 2019 |
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| IMPLANT FOR SUBCUTANEOUS OR INTRACUTANEOUS INJECTION | 1998 |
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| INJECTABLE COMPOSITION WITH SUSPENDED RELEASE CONTAINING A CONJUGATE OF A FILLER WITH POLY-L-LACTIC ACID, A FILLER WITH HYALURONIC ACID AND A BIOACTIVE MATERIAL, AND A METHOD FOR ITS PREPARATION | 2020 |
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RU2777623C1 |
