SOLID-PHASE METHOD OF PRODUCTION OF WATER-SOLUBLE BIOACTIVE NANOCOMPOSITE BASED ON HYALURONIC ACID MODIFIED BY CITRIC ACID AND GOLD NANOPARTICLES Russian patent published in 2014 - IPC C08B37/08 B82B3/00 C08L5/08 

FIELD: biotechnology.

SUBSTANCE: method of production of the water-soluble bioactive nanocomposite comprising salt of hyaluronic acid modified by citric acid or salt of citric acid, as a matrix, and gold nanoparticles as the filler is carried out by chemical interaction of solid-phase powders of salt of hyaluronic acid, citric acid or salt of citric acid and aurichlorohydric acid or salt of gold under the temperature from -18° to 125°C, under conditions of simultaneous action of pressure from 50 to 1000 MPa and the shear deformation in a mechanochemical reactor.

EFFECT: invention enables to obtain water-soluble bioactive nanocomposite with reliably predictable characteristics, namely the high yield of the target product, high gold content, controlled size of gold nanoparticles, narrow distribution by size of nanoparticles of gold, significant increase in resistance of the composite during long storage the above parameters of the composite are maintained for at least one year, the method is carried out in the absence of the liquid medium and does not require the stage of purification and concentration.

20 cl, 18 ex