METHOD OF PRODUCING (1-CYCLOPROPYL-6-FLUORO-1,4-DIHYDRO-8-METHOXY-7-[(4aS,7aS)-OCTAHYDRO-6H-PYRROLO[3,4-B]PYRIDIN-6-YL]-4-OXO-3-QUINOLINECARBOXYLIC ACID Russian patent published in 2018 - IPC C07D471/04

Abstract RU 2641699 C2

FIELD: chemistry.

SUBSTANCE: invention relates to the field of organic chemistry, namely to the method of producing (1-cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-[(4aS,7aS)-octahydro-6H-pyrrolo [3,4-b]pyridin-6-yl]-4-oxo-3-quinolinecarboxylic acid of the formula (6), which comprises adding tert-butyl octahydro-1H-pyrrolo [3,4b] pyridine-1-carboxylate into a compound of the formula to form a compound of the formula

, reacting the compound (2) with triethylorthoformate in acetic anhydride to form a compound of the formula , attaching a cyclic amine to the compound of the formula (3) to form a compound of the formula ; cyclizing a compound of the formula (4) under alkaline conditions to form a compound of the formula ; cleaving the Boc protecting group from the compound of the formula (5) to form the final compound of the formula .

EFFECT: improved method of producing acid of the formula, the method is characterized by its simplicity, economy, and low environmental risk.

5 cl, 5 dwg, 5 ex

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RU 2 641 699 C2

Authors

Derkach Nataliya Mykolaivna

Dates

2018-01-22—Published

2013-06-05—Filed