FIELD: medicine.
SUBSTANCE: group of inventions relates to treatment and/or prevention of vestibular disorders. Disclosed is use of a selective antagonist of H4 histamine receptors, selected from a group consisting of 1-[(5-chloro-1H-benzimidazol-2-yl)carbonyl]-4-methylpiperazine, 1-[(5-chloro-1H-indol-2-yl)carbonyl]-4-methylpiperazine, 4-((3R)-3-aminopyrrolidin-1-yl)-6,7-dihydro-5H-benzo[6,7]cyclohepta[1,2-d]pyrimidin-2-ylamine, or cis-4-(piperazin-1-yl)-5,6,7a,8,9,10,11,11a-octahydrobenzofuro[2,3-h]quinazolin-2-amine for treatment and/or prevention of vestibular disorders and composition for same purpose containing said compounds.
EFFECT: technical result consists in reducing rate of spontaneous nystagmus and reduced excitability of vestibular neurons.
6 cl, 4 dwg
| Title | Year | Author | Number |
|---|---|---|---|
| COMPOUNDS OF THIENOPYRIMIDINE | 2013 |
|
RU2637925C2 |
| PHOSPHOINOSITIDE-3-KINASE INHIBITORS AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAID INHIBITORS | 2007 |
|
RU2437888C2 |
| ACYLATED 6,7,8,9-TETRAHYDRO-5H-BENZOCYCLOHEPTENYLAMINES AND THEIR USING AS PHARMACEUTICAL PREPARATIONS | 2002 |
|
RU2301797C2 |
| COMBINATION OF AURORA KINASE INHIBITORS AND ANTI-CD20 ANTIBODIES | 2009 |
|
RU2535032C2 |
| 2-PHENYLAMINOPYRIMIDINE DERIVATIVES AS LEUCINE-RICH REPEAT KINASE 2 (LRRK2) MODULATORS FOR TREATMENT OF PARKINSON'S DISEASE | 2012 |
|
RU2661197C2 |
| HETEROCYCLIC INHIBITORS OF Hh-SYGNAL CASCADE, BASED ON THEM MEDICINAL COMPOSITIONS AND METHOD OF TREATING DISEASES INDUCED BY ABBARANT ACTIVITY OF Hh-SIGNAL SYSTEM | 2007 |
|
RU2364597C1 |
| PHARMACEUTICAL COMPOUNDS | 2007 |
|
RU2443706C2 |
| Axl INHIBITORS APPLICABLE IN COMBINATION THERAPY FOR PREVENTING, RELIEVING OR TREATING METASTATIC CANCER | 2010 |
|
RU2555326C2 |
| DERIVATIVES OF BENZIMIDAZOL INHIBITING FACTOR Xa | 2004 |
|
RU2346944C2 |
| ANTAGONISTS OF PEPTIDE RECEPTOR FIXED WITH CALCITONIN GENE | 2003 |
|
RU2341526C2 |
