FIELD: pharmacology.
SUBSTANCE: group of inventions relates to pharmaceutical compositions of a neuroleukin-1 antagonist for intravenous administration and discloses a pharmaceutical composition comprising (5S,8S)-8-[{(1R)-1-(3,5-Bis(trifluoromethyl)phenyl)ethoxy}-methyl]-8-phenyl-1,7-diazaspiro[4,5]decan-2-one (compound 1) or pharmaceutically acceptable salts, hydrates or prodrugs thereof, and a pharmaceutically acceptable carrier, a method for treatment of nausea and/or vomiting, including acute delayed nausea and/or vomiting associated with the initial and repeated courses of highly emetogenic or moderately emetogenic chemotherapy, including CINV treatment method, a method for hemolysis minimization using the said pharmaceutical composition.
EFFECT: increased efficiency of treatment.
34 cl, 13 dwg, 21 tbl, 8 ex
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