FIELD: biotechnology.
SUBSTANCE: presented single-domain and oligomeric antibodies contain an antigen-binding amino acid sequence, selected from a group consisting of sequences SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO: 3, SEQ ID NO: 4, SEQ ID NO: 5, SEQ ID NO: 6, SEQ ID NO: 7, SEQ ID NO: 8, SEQ ID NO: 9, SEQ ID NO: 10, on the basis of which compositions, intended for the prevention and treatment of infection of mammals caused by Ebola virus, are created.
EFFECT: proposed antibodies bind to the GP protein of the Ebola virus and have a virus-neutralizing activity and protect against infection and development of the infection in vivo.
6 cl, 10 dwg, 4 tbl, 9 ex
| Title | Year | Author | Number |
|---|---|---|---|
| STRAINS OF HYBRID CELLS OF ANIMALS MUS_ MUSCULUS - PRODUCERS OF MONOCLONAL ANTIBODIES TO PROTEIN GP OF EBOLA VIRUS (SUBTYPE ZAIRE) AND MONOCLONAL ANTIBODIES TO PROTEIN GP OF EBOLA VIRUS (SUBTYPE ZAIRE) | 2017 |
|
RU2686630C1 |
| IMMUNOGEN PEPTIDES AND "EPIVAKEBOL" VACCINE AGAINST EBOLA FEVER WITH APPLICATION OF INDICATED PEPTIDES | 2017 |
|
RU2635998C1 |
| IMMUNOBIOLOGICAL AGENT FOR INDUCTION OF IMMUNE RESPONSE TO FILOVIRUSES: EBOLAVIRUS AND/OR MARBURGVIRUS, METHOD OF USING IMMUNOBIOLOGICAL AGENT | 2021 |
|
RU2760439C1 |
| MONOCLONAL ANTIBODY, BINDING WITH EBOLA VIRUS GLYCOPROTEIN, DNA FRAGMENTS CODING THIS ANTIBODY, AND ANTIGEN-BINDING FRAGMENT | 2015 |
|
RU2630304C2 |
| MONOCLONAL ANTIBODY, BINDING WITH EBOLA VIRUS GLYCOPROTEIN, DNA FRAGMENTS CODING THIS ANTIBODY, AND ANTIGEN-BINDING FRAGMENT | 2015 |
|
RU2639533C2 |
| MONOCLONAL ANTIBODY, LINKING WITH E-BIR VIRUS GLOBE-PROTEIN, DNA FRAGMENTS CODING THIS ANTIBODY AND ANTIGEN-BINDING FRAGMENT | 2016 |
|
RU2644334C2 |
| IMMUNOBIOLOGICAL AGENT AND METHOD FOR USE THEREOF TO INDUCE SPECIFIC IMMUNITY AGAINST EBOLA VIRUS (VERSIONS) | 2015 |
|
RU2578160C1 |
| IMMUNOBIOLOGICAL AGENT AND METHOD FOR USE THEREOF TO INDUCE SPECIFIC IMMUNITY AGAINST EBOLA VIRUS | 2015 |
|
RU2578159C1 |
| RECOMBITANT PLASMID DNA pET21-VP40VE CONTAINING THE GENE FOR THE MATRIX PROTEIN VP40 OF EBOLA VIRUS AND THE RECOMBITANT PROTEIN VP40-VE OBTAINED AS A RESULT OF THE GENE EXPRESSION FOR THE PROTEIN VP40 OF EBOLA VIRUS USING THE RECOMBITANT PLASMID DNA pET21-VP40VE AND EXHIBITING IMMUNOGENIC AND ANTIGENIC PROPERTIES | 2020 |
|
RU2742511C1 |
| RECOMBINANT PLASMID DNA PET21-NPVE CONTAINING NUCLEOLOPROTEIN (NP) GENE OF EBOLA VIRUS AND RECOMBINANT PROTEIN NP-VE, OBTAINED AS RESULT OF EXPRESSION OF NP GENE OF EBOLA VIRUS USING RECOMBINANT PLASMID DNA PET21-NPVE AND POSSESSING IMMUNOGENIC AND ANTIGENIC PROPERTIES | 2020 |
|
RU2739505C1 |
