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IPC

A61K39/12(2006-01-01)

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Application

2015104928/10, 2015-02-13

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Start date

2015-02-13

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Actual filing date

2015-02-13

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Published

2016-03-20

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Inventor

Logunov Denis JurevichShmarov Maksim MikhajlovichTutykhina Irina LeonidovnaZubkova Olga VadimovnaShchebljakov Dmitrij ViktorovichLysenko Andrej AleksandrovichShcherbinin Dmitrij NikolaevichDolzhikova Inna VadimovnaDzharullaeva Alina ShakhmirovnaArtemicheva Natalja MikhajlovnaBurmistrova Darja AndreevnaTukhvatulin Amir IldarovichPantjukhov Vladimir BorisovichSyromjatnikova Svetlana IvanovnaShatokhina Irina ViktorovnaBorisevich Sergej VladimirovichNaroditskij Boris SavelevichGintsburg Aleksandr Leonidovich

(73)

Holder

Federalnoe Gosudarstvennoe Bjudzhetnoe Uchrezhdenie Nauchno-Issledovatelskij Tsentr Epidemiologii I Mikrobiologii Imeni Pochetnogo Akademika N.F. Gamalei" Ministerstva Zdravookhranenija Rossijskoj Federatsii" Im. N.F.Gamalei" Minzdrava Rossii)

IMMUNOBIOLOGICAL AGENT AND METHOD FOR USE THEREOF TO INDUCE SPECIFIC IMMUNITY AGAINST EBOLA VIRUS Russian patent published in 2016 - IPC A61K39/12

Abstract RU 2578159 C1

FIELD: medicine; virology.

SUBSTANCE: developed immuno-biological agent for inducing specific immune response to Ebola virus. Agent contains human recombinant adenovirus serotype 5 containing expressing cassette with gene insertion GP Ebola virus, and human recombinant adenovirus serotype 5 containing expressing cassette with gene insertion NP Ebola virus. GP gene of Ebola virus gene is GP Ebola virus /H.sapiens-wt/SLE/2014/Makona-G3735.1 GenBank ID KM233056 with modified nucleotide sequence selected from SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO: 3, SEQ ID NO: 4, and gene NP Ebola virus gene is NP Ebola virus /H.sapiens-wt/SLE/2014/Makona-G3735.1 GenBank ID KM233056 SEQ ID NO: 5. Immuno-biological agent additionally contains hyaluronidase. Also disclosed is method of using immuno-biological agent for inducing specific immunity to Ebola by introducing immuno-biological agent in effective amount. Presented inventions more effectively induce intensified immune response against Ebola virus in comparison with similar facilities due to features of used genetic constructs, optimising codons nucleotide sequences coding protein of Ebola virus, as well as amino acid sequences of proteins of Ebola virus.

EFFECT: presented inventions can be used in medicine as specific preventive agent for diseases caused by Ebola virus.

3 cl, 9 dwg, 2 tbl, 6 ex

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RU 2 578 159 C1

Authors

Logunov Denis Jurevich

Shmarov Maksim Mikhajlovich

Tutykhina Irina Leonidovna

Zubkova Olga Vadimovna

Shchebljakov Dmitrij Viktorovich

Lysenko Andrej Aleksandrovich

Shcherbinin Dmitrij Nikolaevich

Dolzhikova Inna Vadimovna

Dzharullaeva Alina Shakhmirovna

Artemicheva Natalja Mikhajlovna

Burmistrova Darja Andreevna

Tukhvatulin Amir Ildarovich

Pantjukhov Vladimir Borisovich

Syromjatnikova Svetlana Ivanovna

Shatokhina Irina Viktorovna

Borisevich Sergej Vladimirovich

Naroditskij Boris Savelevich

Gintsburg Aleksandr Leonidovich

Dates

2016-03-20—Published

2015-02-13—Filed