FIELD: biotechnology.
SUBSTANCE: invention relates to a monoclonal antibody selectively binding the Ebola virus glycoprotein with a dissociation constant of complex 2.6∙10-9⋅M, as well as to an isolated DNA fragment encoding the light and heavy chain regions of the said antibody, and an antigen-binding fragment of the said monoclonal antibody. The specificity of the monoclonal antibody to the Ebola virus glycoprotein was confirmed by immunoassay and immunoblotting. The amino acid and nucleotide sequences of the variable domains of the monoclonal antibody are determined.
EFFECT: invention allows preparation of new monoclonal antibodies selectively binding the Ebola virus glycoprotein.
4 cl, 4 dwg, 2 tbl, 3 ex
| Title | Year | Author | Number |
|---|---|---|---|
| MONOCLONAL ANTIBODY, BINDING WITH EBOLA VIRUS GLYCOPROTEIN, DNA FRAGMENTS CODING THIS ANTIBODY, AND ANTIGEN-BINDING FRAGMENT | 2015 |
|
RU2639533C2 |
| MONOCLONAL ANTIBODY, LINKING WITH E-BIR VIRUS GLOBE-PROTEIN, DNA FRAGMENTS CODING THIS ANTIBODY AND ANTIGEN-BINDING FRAGMENT | 2016 |
|
RU2644334C2 |
| NEUTRALIZING MONOCLONAL ANTIBODY BINDING TO RABIES VIRUS GLYCOPROTEIN G, DNA FRAGMENTS CODING SAID ANTIBODY, AND ANTIGEN-BINDING FRAGMENT | 2017 |
|
RU2718835C2 |
| HUMANISED ANTIBODY AND ANTIGENBINDING FRAGMENT (Fab), WHICH BINDS WITH HUMAN INTERFERON-γ, DNA FRAGMENTS CODING CLAIMED ANTIBODY AND ANTIGEN-BINDING FRAGMENT, CELL, TRANSFORMED BY DNA FRAGMENT, AND METHOD OF OBTAINING CLAIMED ANTIBODY AND ANTIGEN-BINDING FRAGMENT | 2013 |
|
RU2539752C2 |
| MONOCLONAL ANTIBODY TO HUMAN INTERFERON BETA-1A | 2018 |
|
RU2728696C2 |
| MONOCLONAL ANTIBODY CAPABLE OF NEUTRALIZING BIOLOGICAL ACTIVITY OF HUMAN INTERFERON BETA 1A | 2018 |
|
RU2729391C2 |
| HUMANISED NEUTRALIZING ANTIBODY TO HUMAN INTERFERON-BETA | 2019 |
|
RU2737466C1 |
| HUMANISED 5D3HU ANTIBODY BINDING TO THE PRAME TUMOUR ANTIGEN, DNA FRAGMENTS ENCODING SAID ANTIBODY, AND ANTIGEN-BINDING FRAGMENT OF THE ANTIBODY | 2020 |
|
RU2761876C1 |
| HUMANIZED ANTIBODY 6H8HU, BINDING TO TUMOUR ANTIGEN PRAME, DNA FRAGMENTS CODING SAID ANTIBODY AND ANTIGEN-BINDING ANTIBODY FRAGMENT | 2020 |
|
RU2768737C1 |
| HUMANISED ANTIGEN-BINDING FRAGMENTS (Fab) AGAINST RABIES VIRUS, ISOLATED DNA FRAGMENT, CODING Fab AGAINST RABIES VIRUS, YEAST CELL, TRANSFORMED BY DNA FRAGMENT, AND METHOD OF OBTAINING Fab AGAINST RABIES VIRUS WITH APPLICATION OF YEASTS | 2010 |
|
RU2440412C2 |
