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2 645 675

(13)

(51)

IPC

C07D453/02(2006-01-01)

A61K31/439(2006-01-01)

A61P3/00(2006-01-01)

(21) (22)

Application

2013146550, 2012-03-16

(24)

Start date

2012-03-16

(22)

Actual filing date

2012-03-16

(45)

Published

2018-02-27

(72)

Inventor

Burke ElizSelatka KassandraKhert BredfordMetts MarkusChzhao ChzhunSkerldzh RenatoSyan IbinDzhansiziks KetrinMarshall DzhonChen SenShojle RonaldKabrera-Salazar MarioGud Endryu

(73)

Holder

Dzhenzim Korporejshn

GLUCOSYLCERAMIDE-SYNTHASE INHIBITORS Russian patent published in 2018 - IPC C07D453/02 A61K31/439 A61P3/00

Abstract RU 2645675 C2

FIELD: pharmacology.

SUBSTANCE: invention relates to glucosylceramide synthase (GCS) inhibitors of formula

as well as to a method for treatment with these compounds.

EFFECT: new compounds are obtained which can be used to treat a disease of lysosomal accumulation, wherein the said lysosomal accumulation disease is the result of a defect in the glycosphingolipid pathway.

33 cl, 20 dwg, 1 tbl, 127 ex

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RU 2 645 675 C2

Authors

Burke Eliz

Selatka Kassandra

Khert Bredford

Metts Markus

Chzhao Chzhun

Skerldzh Renato

Syan Ibin

Dzhansiziks Ketrin

Marshall Dzhon

Chen Sen

Shojle Ronald

Kabrera-Salazar Mario

Gud Endryu

Dates

2018-02-27—Published

2012-03-16—Filed