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2 489 423

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IPC

C07D209/60(2006-01-01)

C07D403/12(2006-01-01)

C07D403/14(2006-01-01)

C07H17/02(2006-01-01)

A61K31/403(2006-01-01)

A61P35/00(2006-01-01)

(21) (22)

Application

2008135440/04, 2007-02-02

(24)

Start date

2007-02-02

(22)

Actual filing date

2007-02-02

(45)

Published

2013-08-10

(72)

Inventor

Besker Patrik KhenriDe Grot Fransiskus Marinus KhendrikusTittse Lutts F.Major FeliksJosten Jokhannes Al'Bertus FrederikusSpejker Khenri Jokhannes

(73)

Holder

Sintarga B.V.Georg-August-Univerzitet Gettingen Shtiftung Ehffentlikhen Rekhts Berajkh Khumanmeditsin)

WATER-SOLUBLE ANALOGUES CC-1065 AND THEIR CONJUGATES Russian patent published in 2013 - IPC C07D209/60 C07D403/12 C07D403/14 C07H17/02 A61K31/403 A61P35/00

Abstract RU 2489423 C2

FIELD: biotechnologies.

SUBSTANCE: invention relates to new compounds of the formula I:

or its pharmaceutically acceptable salts, where values R¹, R², R³, R^3', R⁴, R^4', X², X¹, X³, X⁴, X⁵, R⁶, R⁷, R^5', R^6', R^7', R^14', R⁸, R⁹, R¹⁰, R¹¹a, b, c are specified in the clause 1 of the formula.

EFFECT: compounds demonstrate antitumoral activity and may be used to produce a pharmaceutical composition for tumor treatment in a mammal.

14 cl, 18 dwg, 1 tbl, 52 ex

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RU 2 489 423 C2

Authors

Besker Patrik Khenri

De Grot Fransiskus Marinus Khendrikus

Tittse Lutts F.

Major Feliks

Josten Jokhannes Al'Bertus Frederikus

Spejker Khenri Jokhannes

Dates

2013-08-10—Published

2007-02-02—Filed