FIELD: pharmaceutics.
SUBSTANCE: invention relates to compounds of formula (I) or to the pharmaceutically acceptable salts thereof, and optical isomers. In formula (I) Ar1 is selected from a group consisting of phenyl, pyridyl, pyrazinyl, pyridazinyl, pyrimidinyl and triazinyl; each of which is optionally has from one to two substituents, Ar2 is selected from the group consisting of pyrazolyl, imidazolyl and triazolyl; each of which has from one to three substituents, and the remaining groups and substituents have given in the claims the definitions. These compounds are CCR1 receptor antagonists and in vivo exhibit anti-inflammatory activity.
(I).
EFFECT: these compounds can be used in pharmaceutical compositions, CCR1-mediated diseases methods of treating and as a control in the competitive CCR1 antagonists identification tests.
24 cl, 1 tbl, 75 ex
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