FIELD: chemistry.
SUBSTANCE: invention relates to a compound of formula I: 
, or pharmaceutically acceptable salts thereof. Value of radicals is given in the claims. Also disclosed are a series of specific compounds, a pharmaceutical composition, and the use of a compound of formula I.
EFFECT: compounds are tropomyosin-related kinase (Trk) family protein kinase inhibitors, and therefore can be used in the treatment of a disease or disorder mediated by Trk receptors.
18 cl, 2 tbl, 218 ex
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