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2 615 130

(13)

C2

(51)

IPC

C07D401/12(2006-01-01)

C07D401/14(2006-01-01)

C07D403/14(2006-01-01)

C07D405/14(2006-01-01)

C07D407/14(2006-01-01)

C07D413/14(2006-01-01)

C07D417/14(2006-01-01)

C07D471/04(2006-01-01)

C07D487/04(2006-01-01)

A61K31/4427(2006-01-01)

A61K31/495(2006-01-01)

A61K31/505(2006-01-01)

A61K31/53(2006-01-01)

A61P35/00(2006-01-01)

(21) (22)

Application

2012118667, 2010-10-05

(24)

Start date

2010-10-05

(22)

Actual filing date

2010-10-05

(45)

Published

2017-04-04

(72)

Inventor

Arndt DzhozefChan TimotiGukian KevinKumaravel GianasambandamLi Ven-CherngLin Edvard In-ShianSkott DenielSun LikhunTomas DzhermejnVan Vloten KurtVan DepinChzhan LejErlanson Deniel

(73)

Holder

Millennium Farmasyutikalz, InkSanesis Farmasyutikalz, Ink.

HETEROCYCLIC COMPOUNDS USEFUL AS PDK1 INHIBITORS Russian patent published in 2017 - IPC C07D401/12 C07D401/14 C07D403/14 C07D405/14 C07D407/14 C07D413/14 C07D417/14 C07D471/04 C07D487/04 A61K31/4427 A61K31/495 A61K31/505 A61K31/53 A61P35/00 

Abstract RU 2615130 C2

FIELD: chemistry.

SUBSTANCE: present invention relates to novel compounds of general formulae II, III, IV and V, where values of radicals are given in description, or pharmaceutically acceptable salts thereof, which can be used as PDK1 inhibitors.

EFFECT: present invention also relates to pharmaceutical compositions based thereon and to methods of treating cancer, mediated by protein kinase PDK1.

32 cl, 2 tbl, 445 ex

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RU 2 615 130 C2

Authors

Arndt Dzhozef

Chan Timoti

Gukian Kevin

Kumaravel Gianasambandam

Li Ven-Cherng

Lin Edvard In-Shian

Skott Deniel

Sun Likhun

Tomas Dzhermejn

Van Vloten Kurt

Van Depin

Chzhan Lej

Erlanson Deniel

Dates

2017-04-04—Published

2010-10-05—Filed

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