FIELD: medicine.
SUBSTANCE: invention relates to peptides with a cytotoxic effect, of the general formula R3-Phe-D-Trp-Lys(R1)-Thr-R2, where R1 is H or t-butyloxycarbonyl; R2 is a 1-amino-adamantyl, 1-amino-(1-adamantyl)ethyl group; R3 is R4-Cys(R5) - or 3-R4-thiazolidine-4-carbonyl, where R4 is H or t-butyloxycarbonyl; R5 is H or t-butyloxycarbonyl or acetomidomethyl.
EFFECT: high resistance of peptides to enzymatic degradation; a possibility of both oral and parenteral administration to the body.
2 cl, 2 tbl, 11 ex
| Title | Year | Author | Number |
|---|---|---|---|
| SHORT PEPTIDES WITH ANTITUMOUR ACTIVITY | 2016 |
|
RU2648357C2 |
| METHOD FOR PRODUCING BOC-THZ-PHE-D-TRP-LYS(BOC)-THR-NHCHCHNH-DOTA CONJUGATE BEING A PRECURSOR FOR ANTI-TUMOR RADIOPHARMACEUTICS | 2022 |
|
RU2795447C1 |
| PROTECTED DERIVATIVES OF OCTREOTIDE | 2001 |
|
RU2196144C1 |
| SOLID-PHASE SYNTHESIS OF PEPTIDES WITH BOC AND FMOC PROTECTIVE GROUPS | 2007 |
|
RU2439075C2 |
| METHOD OF OBTAINING PEPTIDES | 0 |
|
SU639446A3 |
| PEPTIDE VECTORS | 2004 |
|
RU2361876C2 |
| CHIMERIC ANALOGS OF SOMATOSTATIN-DOPAMINE | 2002 |
|
RU2277539C2 |
| PEPTIDE DERIVATIVE, METHOD OF TREATMENT OF CANCER PATIENT | 1994 |
|
RU2133252C1 |
| PEPTIDE AND A METHOD OF ITS SYNTHESIS | 1994 |
|
RU2067000C1 |
| CONJUGATES OF CYTOTOXIC AGENTS WITH PEPTIDES | 2007 |
|
RU2457218C2 |
