FIELD: medicine.
SUBSTANCE: invention concerns a short peptide with a cytotoxic activity of the general formula R3-Phe-D-Trp-Lys (R1)-Thr-R2, where R1 is H, t-butyloxycarbonyl; R2 is a hydroxy, methoxy, amino, hydroxyamino, aminobenzyl, 1-aminonaphthyl group; R3 - tert-butyloxycarbonyl-Cys (R4) or 3-R5-thiazolidine-4-carbonyl, where R4 - H or t-butyloxycarbonyl, acetamidomethyl; R5 - H or t-butyloxycarbonyl.
EFFECT: invention provides high cytotoxic activity and resistance to enzymatic degradation, which allows oral administration to the body, in addition to parenteral, administered subcutaneously, intravenously, intramuscularly and intraperitoneally.
2 tbl, 19 ex
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|---|---|---|---|
| ADAMANTIL DERIVATIVES OF SHORT PEPTIDES WITH ANTITUMOUR ACTIVITY | 2016 |
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| METHOD FOR PRODUCING BOC-THZ-PHE-D-TRP-LYS(BOC)-THR-NHCHCHNH-DOTA CONJUGATE BEING A PRECURSOR FOR ANTI-TUMOR RADIOPHARMACEUTICS | 2022 |
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| METHOD OF OBTAINING PEPTIDES | 0 |
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| METHOD FOR PRODUCING CYCLIC PEPTIDE-OCTREOTIDE | 2010 |
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