BENZIMIDAZOLES AS CNS ACTIVE AGENTS Russian patent published in 2018 - IPC C07D401/14 C07D403/04 A61K31/4155 A61K31/4178 A61K31/4184 A61K31/4425 A61P25/00 

FIELD: organic chemistry.

SUBSTANCE: invention relates to the field of organic chemistry, namely to compounds of general formula I, where R¹ – hydrogen atom, lower alkyl, halogen atom or lower alkyl substituted by at least three halogen atoms; R² – hydrogen or halogen atom; X¹ – N or CH; X² – N or CH; with the proviso that only one of X¹ or X² is N; X³ – C(R) or N; and R – hydrogen atom, lower alkyl, halogen atom, lower alkyl substituted by at least three halogen atoms, lower alkoxy or SO₂-lower alkyl; Invention also relates to a pharmaceutical composition based on a compound of formula I, its use and a method of treating diseases based on the use of a compound of formula I. .

EFFECT: technical result: new heterocyclic compounds useful for stimulating neurogenesis from neuronal stem cells were obtained.

16 cl, 30 ex