IMIDAZOPYRIDINYL COMPOUNDS AND USE THEREOF FOR TREATING NEURODEGENERATIVE DISORDERS Russian patent published in 2025 - IPC C07D471/04 C07D519/00 A61K31/437 A61K31/444 A61K45/06 A61P25/28 

FIELD: chemistry.

SUBSTANCE: invention relates to a compound of formula (I) or a pharmaceutically acceptable salt thereof. In formula (I) the values of radicals are as follows: R¹ is cyclopropyl substituted with one or two halogen groups; R² and R³ are -H; R⁴ is selected from a group consisting of 6-membered aryl, , , , and , wherein said 6-membered aryl is optionally substituted with one to three groups selected from the group consisting of halogen, hydroxyl, C₁-C₁₂alkyl, C₃-C₁₂cycloalkyl, C₁-C₁₂haloalkyl, C₁-C₁₂hydroxyalkyl, C₁-C₁₂alkoxy-C₁-C₁₂alkyl, C₁-C₁₂alkoxy-C₁-C₁₂alkoxy, di-C₁-C₁₂alkylaminoC₁-C₁₂alkyl, -CH₂NHC(O)CH₃, -NR_aR_b, -NR_aC(=O)R_b, -OR_a, -CN, -C(=O)R_a, -C(=O)OR_a, -SR_a, furanyl, pyrrolyl and pyrazolyl; R^a and R^b independently represent -H or C₁-C₁₂alkyl; R⁵ is H, halogen or C₁-C₁₂alkyl. Also disclosed is a compound selected from a group of individual compounds specified in the claim, and a pharmaceutical composition containing said compounds.

EFFECT: disclosed compounds are c-abl and/or LRRK2 kinase inhibitors and can be used to treat neurodegenerative diseases.

24 cl, 2 tbl, 14 ex