ZINC HALIDE MEDIATED CYCLIZATION PROCESS LEADING TO TRICYCLIC INDOLES Russian patent published in 2018 - IPC C07D209/88 

Abstract RU 2647867 C2

FIELD: chemistry.

SUBSTANCE: invention relates to organic chemistry, specifically to a process for preparation of tricyclic indole compounds of formula Z. Method comprises cyclizing a compound having formula Y by introducing a zinc halide in a suitable solvent into a solution of said compound having formula Y, said introduction comprising a first addition and a second addition performed at least 6 hours after said first addition.

, .

EFFECT: process provides improved conversion, which increases yield and avoids significant treatment of the cyclized product.

8 cl, 1 tbl, 1 ex

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RU 2 647 867 C2

Authors

Nilsen Sondre

Mokkapati Umamakheshvar P.

Dates

2018-03-21Published

2013-11-29Filed