CHIMERIC THERAPEUTIC ANTI-CD-37 ANTIBODY HH1 Russian patent published in 2018 - IPC C07K16/28 C12N15/13 C12N5/10 C12N15/63 A61K39/395 A61K51/10 A61P35/02

Abstract RU 2658438 C2

FIELD: immunology.

SUBSTANCE: present invention refers to immunology. Antibody molecule that binds to human CD37 and that has constant chains of human origin. DNA molecule encoding such an antibody, an expression vector, a host cell, and a method for producing an antibody are also contemplated. Also described is a radioimmunoconjugate based on said antibody and a kit for the production thereof, as well as pharmaceutical compositions, a method for eliminating B-cells and a method for treating B-cell malignancies. Chimeric antibody of the present invention mediates antibody-dependent cell-mediated cytotoxicity (ADCC) in a greater degree than the Rituximab antibody.

EFFECT: due to the ability to bind human CD37 and mediate ADCC, the proposed antibody can be further used in therapy.

11 cl, 7 dwg, 14 ex, 3 tbl

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RU 2 658 438 C2

Authors

Larsen Roj Kh.

Dale Dzhostejn

Dates

2018-06-21—Published

2012-12-12—Filed