NOVEL RADIOIMMUNOCONJUGATES AND USE THEREOF Russian patent published in 2018 - IPC A61K51/10 A61P35/02 

FIELD: biochemistry.

SUBSTANCE: invention relates to biochemistry, in particular to a radioimmunoconjugate binding human CD37, which comprises an CD37 antibody, a chelating linker and a radionuclide selected from group consisting of ¹⁷⁷Lu, ²¹²Pb, ²²⁵Ac, ²²⁷Th and ⁹⁰Y. Also disclosed is a pharmaceutical composition for treating B-cell neoplasia comprising said radioimmunoconjugate. Invention also relates to a kit for producing a radioimmunoconjugate, binding human CD37, comprising said antibody, as well as two or more vials, wherein one vial contains a conjugate comprising a chelator attached to a CD37 antibody, and the second vial contains a radionuclide selected from group consisting of ¹⁷⁷Lu, ²¹²Pb, ²²⁵Ac, ²²⁷Th and ⁹⁰Y.

EFFECT: invention provides the effective treatment of B-cell neoplasia.

14 cl, 8 dwg, 10 ex, 5 tbl