DINITRODIBENZO-18-CROWN-6 CIS- AND TRANS-ISOMERS PRODUCTION METHOD Russian patent published in 2018 - IPC C07D323/00 

FIELD: technological processes.

SUBSTANCE: invention relates to the dinitrodibenzo-18-crown-6 cis- and trans-isomers production process, which includes the following steps: 20–25 % suspension of dibeno-18-crown-5 heating in the acetonitrile to 60–65 °C, concentrated nitric acid to the heated suspension drop by drop addition, followed by the reaction mass holding at a temperature of 60–65 °C for 20–40 minutes, cooling down precipitate to the room temperature and its filtering, acetic acid addition to the filtered precipitate, then heating the reaction mass until boiling and its boiling for 0.5–1.0 hours. After that, performing the dinitrodibenzo-18-crown-6 trans- and cis-isomers isolation from the reaction mass, at that, the trans isomer is isolated by filtration from the hot reaction mass, and the cis-isomer is isolated from the cooled down to 5 °C filtrate, after which the produced isomers are washed with water until neutral reaction and dried at 60 °C. Produced are: trans-dinitrodibenzo-18-crown-6 with the yield of 37.9 % and melting point of 246–249 °C; cis-dinitrodibenzo-18-crown-6 with the yield of 46.5 % and melting point of 208–210 °C. Dibenzocrown-ethers functional derivatives, namely, the dinitrodibenzo-18-crown-6 isomers, can be used as compound blocks in the supramolecular systems and polymeric materials.

EFFECT: possibility of the produced dinitrodibenzo-18-crown-6 pure cis- and trans-isomers separation.

1 cl, 2 dwg, 3 ex