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2 397 164

(13)

(51)

IPC

C07D313/14(2006-01-01)

C07D491/44(2006-01-01)

(21) (22)

Application

2007141161/04, 2006-04-06

(24)

Start date

2006-04-06

(22)

Actual filing date

2006-04-06

(45)

Published

2010-08-20

(72)

Inventor

Kemperman Gerardus JokhannesVan Der Linden Jakobus Jokhannes MarijaRider Majkl R.

(73)

Holder

N.V. Organon

INTERMEDIATE COMPOUNDS FOR SYNTHESIS OF TRANS-5-CHLORO-2-METHYL-2,3,3a,12b-TETRAHYDRO-1H-DIBENZ[2,3:6,7]-OXEPINO[4,5-c]PYRROLE Russian patent published in 2010 - IPC C07D313/14 C07D491/44

Abstract RU 2397164 C2

FIELD: chemistry.

SUBSTANCE: invention relates to novel amino acid derivatives of formula or formula , their synthesis methods and their use as intermediate products during synthesis of trans-5-chloro-2-methyl-2,3,3a, 12b-tetrahydro-1H-dibenz[2,3:6,7]oxepino[4,5-c]pyrrole (asenapine), which have central nervous system depressant effect, as well as antihistamine and antiserotonin effect.

EFFECT: use of intermediate compounds I and II considerably increases output of asenapine.

12 cl, 9 ex

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RU 2 397 164 C2

Authors

Kemperman Gerardus Jokhannes

Van Der Linden Jakobus Jokhannes Marija

Rider Majkl R.

Dates

2010-08-20—Published

2006-04-06—Filed