FIELD: biotechnology.
SUBSTANCE: inventions relate to the field of biotechnology and a live attenuated recombinant Koi herpesvirus (KHV), an expression vector comprising the genome of such a virus, an isolated cell, a vaccine, a method for preventing fish disease caused by KHV, and an immunogenic composition. Present live attenuated recombinant Koi herpesvirus includes a genome in which the open reading frame 56 (ORF 56) and the open reading frame 57 (ORF 57) are deleted, for use in a vaccine for the prevention of a disease caused by Koi herpesvirus (KHV) in fish.
EFFECT: inventions make it possible to obtain safe and effective attenuated vaccines for controlling KHV infection.
16 cl, 29 dwg, 3 tbl
| Title | Year | Author | Number |
|---|---|---|---|
| IMMUNISATION OF FISH AGAINST VIRUS INFECTION | 2003 |
|
RU2369635C2 |
| GLYCOPROTEIN GENE (G-GENE) OF RUSSIAN REFERENCE STRAIN ZL-4 OF CARP SPRING VIREMIA VIRUS AND RECOMBINANT PLASMID DNAS pcDNA-G AND pBACarpVax-G EXPRESSING GLYCOPROTEIN GENE AND PROVIDING DEVELOPMENT OF PROTECTIVE IMMUNITY IN FISH AGAINST INFECTION WITH CARP SPRING VIREMIA VIRUS | 2004 |
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| METHOD FOR PRODUCING RECOMBINANT HERPESVIRUSES FOR SIMULTANEOUS TRANSDUCTION AND IMMORTALIZATION OF PRIMARY T-LYMPHOCYTES AND NK CELLS | 2019 |
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| POLYVALENT RECOMBINANT SWINE POX VIRUS | 2017 |
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| RECOMBINANT MODIFIED SMALLPOX VIRUS, ITS USAGE (VERSIONS) AND CELL LINE INFECTED BY VIRUS (VERSIONS) | 1996 |
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| NORTH AMERICAN PORCINE REPRODUCTIVE AND RESPIRATORY SYNDROME (PRRS) VIRUS AND USES THEREOF | 2011 |
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RU2592667C2 |
| METHOD OF PREPARATION OF RECOMBINANT ADENOVIRUS OF BIRDS FOR VACCINATION AGAINST BIRDS FLU VIRUS H5N1 | 2006 |
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RU2326943C1 |
| MUTANT HERPES VIRUS-COMPRISING VACCINE | 1991 |
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RU2236256C2 |
