FIELD: biotechnology.
SUBSTANCE: inventions relate to the field of biotechnology and a live attenuated recombinant Koi herpesvirus (KHV), an expression vector comprising the genome of such a virus, an isolated cell, a vaccine, a method for preventing fish disease caused by KHV, and an immunogenic composition. Present live attenuated recombinant Koi herpesvirus includes a genome in which the open reading frame 56 (ORF 56) and the open reading frame 57 (ORF 57) are deleted, for use in a vaccine for the prevention of a disease caused by Koi herpesvirus (KHV) in fish.
EFFECT: inventions make it possible to obtain safe and effective attenuated vaccines for controlling KHV infection.
16 cl, 29 dwg, 3 tbl
| Title | Year | Author | Number |
|---|---|---|---|
| IMMUNISATION OF FISH AGAINST VIRUS INFECTION | 2003 |
|
RU2369635C2 |
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