FIELD: chemistry.
SUBSTANCE: invention relates to a method for purifying a crude product containing a nonionic iodinated dimeric X-ray contrast agent. Method includes step i) passing a solution of the crude product across membrane (M1) such that monomeric compound impurities and salts cross the membrane (permeate, P1) and the nonionic iodinated dimeric X-ray contrast agent does not pass through the membrane (retentate, R1). As a result, a purified dimeric X-ray contrast agent is obtained whose purity is at least 98%. Monomeric impurities are compounds with a molecular weight from 435 to 900 Da, and membrane (M1) has a cut-off size from 950 to 1200 Da.
EFFECT: proposed method allows to efficiently and with high yield remove monomeric impurities from a crude nonionic iodinated dimeric X-ray contrast agent without the use of chromatography and crystallisation.
7 cl, 1 dwg, 1 ex
| Title | Year | Author | Number |
|---|---|---|---|
| PREPARATION OF INTERMEDIATES OF X-RAY CONTRAST AGENTS | 2013 |
|
RU2659214C2 |
| METHOD AND REAGENT FOR PREPARING A DIAGNOSTIC COMPOSITION | 2014 |
|
RU2662319C2 |
| CONTRAST MEDIA WITH LOW IODINE CONCENTRATION FOR X-RAY IMAGING AND A METHOD FOR X-RAY IMAGING | 2013 |
|
RU2664418C2 |
| X-VISUALISATION AT LOW CONCENTRATIONS OF CONTRAST AGENT AND/OR LOW DOSE OF RADIATION | 2011 |
|
RU2566281C2 |
| CONTRAST AGENTS | 2008 |
|
RU2469021C2 |
| IODINATED ARYL COMPOUNDS AND DIAGNOSTIC COMPOSITION BASED THEREON | 1995 |
|
RU2145955C1 |
| METHOD OF IODISING AROMATIC COMPOUNDS | 2009 |
|
RU2469997C2 |
| LIQUID HYDROCARBON PRODUCT PURIFICATION PROCESS | 2001 |
|
RU2236394C2 |
| PROCESS FOR IODINATION OF PHENOLIC DERIVATIVES | 2011 |
|
RU2563645C2 |
| CONTINUOUS METHOD OF SEPARATION OF THE COLORED MASSES AND-OR THE ASPHALTENE IMPURITIES FROM THE HYDROCARBON MIXTURE | 2002 |
|
RU2311441C2 |
