FIELD: medicine; pharmaceuticals.
SUBSTANCE: group of inventions relates to chemical-pharmaceutical industry and is an aqueous, excipient solution suitable for diluting a diagnostic composition comprising a contrast agent. Excipient solutions comprise a sodium ion concentration of about 100 -140 mM and a calcium ion concentration of about 0.8 - 1.2 mM. Alternatively, the molar ratio between sodium ion concentration and calcium ion concentration is between about 80 and 175. Also provided are methods of making and using the excipient solution, as well as a kit comprising the excipient solutions. Group of inventions allows diluting an iodinated contrast agent with a certain combination of salts, wherein in a wide range of iodine concentrations of 70 to 320 mg I/l.
EFFECT: isotonicity of the diluted solution will be maintained.
32 cl, 1 ex
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