HOST CELLS AND WAYS TO USE Russian patent published in 2018 - IPC C12N1/16 C12N15/81 C12N9/02 C12N9/60 C12N9/90 C07K14/395

Abstract RU 2663587 C2

FIELD: biotechnology.

SUBSTANCE: host cell for producing a recombinant polypeptide comprising a heterologous nucleic acid sequence encoding a Killer Expression (Kex2p) protease is provided, heterologous nucleic acid sequence encoding a Protein disulfide isomerase (Pdi1), and nucleic acid encoding the recombinant polypeptide. Method for producing the recombinant polypeptide comprising culturing said host cell is provided. Host cell for producing the recombinant polypeptide comprising the heterologous nucleic acid sequence encoding the Killer Expression protease (Kex2p) is provided, heterologous nucleic acid sequence encoding the Protein disulfide isomerase (Pdi1), the heterologous nucleic acid sequence encoding an endoplasmic reticulum oxidoreductin (Ero1), and nucleic acid encoding the recombinant polypeptide.

EFFECT: group of inventions makes it possible to increase the production of the recombinant polypeptide.

31 cl, 7 dwg, 1 ex

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RU 2 663 587 C2

Authors

Tszin Yunkhvan

Chzhu Yuan

Dates

2018-08-07—Published

2014-03-06—Filed